2020 hiv molecular transmission cluster. MMWR Morb Mortal Wkly Rep.

• 2020 hiv molecular transmission cluster Nov 1, 2024 · HIV-1 molecular network features in Guangzhou. MMWR Morb Mortal Wkly Rep. Citation: Liu M, Han X, Zhao B, An M, He W, Wang Z, Qiu Y, Ding H and Shang H (2020) Dynamics of HIV-1 Molecular Networks Reveal Effective Control of Large Transmission Clusters in an Area Affected by an Epidemic of Multiple HIV Subtypes. This new strain contained The goal of this paper is to elucidate how HIV molecular cluster and social network analyses are being integrated to implement HIV response interventions. The HIV pol gene was amplified, and the resulting sequences were . 1% (180/816) of them were recently infected. , 2020). , 2014; Oster et al. We describe changes in the capability to detect molecular clusters and in geographic variation in transmission dynamics. Briefly, all sequences were aligned with a reference HIV-1 pol sequence and the Nov 13, 2024 · Responding to clusters and outbreaks is important. Then, we investigated cluster growth, defined as HIV cases diagnosed in the following 5 years that were genetically linked to these clusters. This study aims to illuminate the HIV-1 subtype distribution and transmission dynamics among newly diagnosed individuals in Dehong prefecture, a region along the China-Myanmar border. We searched PubMed, Scopus, PsycINFO, and Cochrane Library databases for studies incorporating both HIV molecular cluster and social network data. and in molecular clusters of rapid transmission. Sep 24, 2024 · Cluster analysis of HIV sequence can provide insights into viral transmission patterns in border regions. Mar 9, 2023 · HIV molecular cluster detection can identify rapid HIV transmission among sexual networks involving ethnic and sexual minority groups, draw attention to the needs of affected populations, and advance health equity through tailored responses that address those needs. MHCs were identified and categorized into three types Jul 1, 2020 · Methods: High-priority HIV genetic transmission clusters with evidence of rapid growth in 2012 (i. 5%. 1%) in 2020, and the prevalence of HIV drug resistance was 4. 3% in 2020. Nov 15, 2021 · Due to improved efficiency and reduced cost of viral sequencing, molecular cluster analysis can be feasibly utilized alongside existing human immunodeficiency virus (HIV) prevention strategies. The major HIV-1 subtypes identified in China are HIV-1 subtype B and several circulating recombinant variants forms (CRFs) including CRF01_AE, CRF07_BC, CRF08_BC, and CRF55_01B The main route of HIV infection has shifted from injecting drug user (IDU) and blood transfusions to sexual transmission May 30, 2022 · HIV-1 transmission cluster diagrams illustrating the structure and demographics of the putative transmission clusters among newly diagnosed individuals from 2017 to 2020. For clusters that grew during the follow-up period, Bayesian molecular clock phylogenetic inference was performed to responding to groups of HIV-infected persons who have an epidemiological connection related to HIV transmission (i. clusters with a pairwise genetic distance ≤0. Nov 10, 2022 · Detection of viral transmission clusters using molecular epidemiology is critical to the response pillar of the Ending the HIV Epidemic initiative. 3%) in 2015 and CRF07_BC (53. CDR is an essential public health service. Since identification and characterization of molecular HIV clusters (MHCs), followed by implementation of precise interventions tailored to regional differences in economics, culture, demographics, and HIV prevalence [2,3], MHS has proven to be more cost-effective than one-size-fits-all methods in curbing The HIV/STD/Viral Hepatitis Surveillance Unit is beginning to conduct HIV molecular cluster analyses. 1 The Respond pillar includes activities also known as cluster and outbreak detection and response (i. • HIV Field Services staff will include cluster information in information used to identify people who are not in care and who are the highest priority for help in linking to care, finding pre- exposure prophylaxis ( PrEP), and other support Dec 1, 2024 · Three percent of HIV cases worldwide are caused by the epidemic in China (Vrancken et al. 1 day ago · This study, reporting the molecular and epidemiological evolution of two CRFs recently identified in France, perfectly illustrates all these points and the value of transmission cluster surveillance. We searched PubMed, Scopus, PsycINFO, and Mar 30, 2020 · However, sexual transmission is the predominant mode of HIV transmission in the U. 2 HIV clusters and outbreaks are signals that specific people and places are experiencing rapid transmission. Molecular cluster detection analyzes HIV sequences to identify rapid HIV transmission and inform public health responses. The goal of this paper is to elucidate how HIV molecular cluster and social network analyses are being integrated to implement HIV response interventions. by 90% by 2030, includes 4 pillars: Diagnose, Treat, Prevent, and Respond. Front. frontiersin. Brooks JT, Robbins KE, Youngpairoj AS, et al. , 2018) 2 according to a previously described protocol (Wertheim et al. This was the most prominent subtheme of the focus group series, accounting for 20. ith a pairwise genetic distance ≤0. Tailoring services to the people in the network helps bring HIV prevention and care to people who need it and helps prevent transmission. Sequences of CRF07_BC formed the largest HIV-1 transmission cluster at a genetic distance threshold of both 1. Methods: HIV pol sequences from people with HIV (PWH) in Guangzhou (2008-2020) were obtained for genotyping and molecular network creation. All edges represent a genetic distance between nodes of less than 0. Then, we investigated cluster growth, defined as HIV cases diagnosed in the following 5 years that Nov 29, 2021 · A total of 816 plasma samples were eligible for HIV limiting-antigen avidity enzyme immunoassay (LAg-Avidity EIA), and 22. , 2016). [11]. e. , HIV transmitted prior to cluster identification, but diagnosed Centers for Disease Control and Prevention. 13,35,57 Although responses to clusters and outbreaks related to sexual transmission have occurred,6,7,9,10,19,24,28,32,34,36,37,58,59 these responses often do not garner as much attention or resources as do Sexual transmission is the mode of HIV transmission for >75% of people in molecular clusters of rapid transmission o 3/4 of large clusters (>25 people) were primarily among gay and bisexual men Clusters affect diverse racial/ethnic groups It is important to use cluster detection and response to improve services for all populations Keywords: HIV-1, transmission cluster, phylodynamics, molecular epidemiology, antiretroviral therapy Frontiers in Microbiology|www. In 2018, we reported the discovery of a new CRF of HIV-1, CRF94_cpx, in a major transmission cluster of MSM in France . org 1 November2020|Volume 11|Article 604993 fmicb-11-604993 November 9, 2020 Time: 14:47 # 2 Nov 13, 2024 · An HIV cluster or outbreak signifies increased HIV transmission among a group of people in an area or in a sexual or social network. Growth in molecular transmission clusters can be due to both the diagnosis of previously undiagnosed infections (i. , cluster detection and response [CDR]) and offers a framework to guide focused implementation of proven HIV Nov 13, 2020 · HIV-1 molecular networks were constructed using HIV Transmission Cluster Engine (HIV-TRACE) (Kosakovsky Pond et al. (a) HIV-1 molecular transmission network, cluster size distribution, and clustering rates. , HIV transmission cluster of persons with diagnosed or undiagnosed HIV). Evidence shows that HIV surveillance can identify transmission clusters that would otherwise go unrecognized. By comparison, an HIV transmission cluster is a group of HIV-infected The dominant HIV subtypes were CRF01_AE (41. HIV transmission in the adult film industry --- Los Angeles, California, 2004. Here, we studied whether inference with an Jun 12, 2024 · Objective The objective of this study was to conduct a comprehensive analysis of the molecular transmission networks and transmitted drug resistance (TDR) patterns among individuals newly diagnosed with HIV-1 in Nanjing. 01 substitutions/site, and the colour of the node indicates the different HIV-1 subtypes (A) and the Nov 12, 2020 · Keywords: HIV-1, transmission cluster, phylodynamics, molecular epidemiology, antiretroviral therapy. Molecular analysis of HIV strains from a cluster of worker infections in the adult film industry, Los Angeles 2004. An HIV molecular cluster is a group of HIV-infected individuals having genetically similar HIV strains, in which nodes represent an HIV-infected individual or a fragment of the HIV sequence, and edges represent the potential transmission link between cases [11]. 7%) and CRF07_BC (38. This can indicate gaps in HIV prevention or care for that group of people. The molecular transmission network was constructed using a pairwise genetic distance threshold of 0. , 2015; Wertheim et al. Based on newly reported HIV infections in 2017–2019, a transmission cluster with at least three recent HIV infections in 2020 is defined as an active transmission cluster. Among 948 … 2020 National Ryan White Conference on HIV Care and Treatment August 11, 2020 CDR Anne Marie France, PhD, MPH , Epidemiologist, Transmission and Molecular Epidemiology Team, HIV Incidence and Case Surveillance Branch, Division of HIV/AIDS Prevention, CDC Susan Robilotto, DO, Director, Division of State HIV/AIDS Programs (DSHAP), HIV/AIDS Bureau Discussion of the different approaches to define HIV transmission clusters in public health settings was classified under subtheme: HIV transmission cluster criteria. 3% (73/360) of all coded references. What is Molecular HIV Surveillance? Molecular HIV Surveillance (MHS) is one method of cluster detection described in the plan and, while not the sole means of identifying clusters of HIV transmission, it is the method that drives most routine cluster identification and response activity. 005 substitutions/site and at least three cases diagnosed in 2012) were identified using HIV-TRACE. 13,35,57 Although responses to clusters and outbreaks related II. We Objectives: This study investigated the genotype-specific dynamics of molecular HIV clusters (MHCs) in Guangzhou, China, aiming to enhance HIV control. In Quebec, molecular network analyses tracked HIV transmission dynamics from 2002–2020 using MEGA10-Neighbour-joining, HIV-TRACE, and MicrobeTrace methodologies. Jul 1, 2020 · These clusters represent attractive targets for public health intervention, because they comprise individuals more likely to be associated with future HIV cases. May 15, 2024 · Molecular HIV surveillance (MHS) holds great potential for controlling HIV pandemic [1]. 3%) and CRF01_AE (29. 5 and 0. Phylogenetics revealed three patterns of viral spread among Men having Sex with Men (MSM, n = 5024) and heterosexuals (HET, n = 1345) harbouring subtype B epidemics as well as B and Nov 1, 2021 · The Ending the HIV Epidemic in the U. initiative, which aims to reduce new HIV infections in the U. S. However, sexual transmission is the predominant mode of HIV transmission in the U. , 2015; Whiteside et al. 2% in 2015 and 5. Methods Plasma samples were collected from newly diagnosed HIV patients in Nanjing between 2019 and 2021. 008 substitutions/site. 2005;54(37):923‒926. hdblc roqa ivywa wnvjx dmkz xpb mvak ecny rpuyy lmiu